I.V. Labetalol during coronary artery surgery.

Abstract

The hemodynamic effects of a fixed dose of 10 mg i.v. Labetalol were evaluated in 9 CAD patients during a surgical procedure for myocardial revascularisation. The results show a significant mean decrease in heart rate (HR) (-13%), systolic blood pressure (SBP) (-16%) and rate pressure product (RPP) (-28%). Other hemodynamic parameters were not significantly affected. These results were confirmed by a clinical study where in a series of 110 CAD patients 21 were treated during the surgical procedure with incremental doses of Labetalol to control high systolic blood pressure and tachycardia. Administration of a mean dose of 24.3 mg of Labetalol resulted in a significant decrease of RPP (-38%). No side effects related to Labetalol were encountered.

• Authors: K Joucken
• Journal: Acta anaesthesiologica Belgica (Acta Anaesthesiol Belg) Vol. 34 Issue 1 Pg. 15-26 ( 1983) ISSN: 0001-5164 [Print] Belgium
• PMID: 6845955 (Publication Type: Journal Article)

Chemical References

• Ethanolamines
• Labetalol

Topics

• Aged
• Blood Pressure (drug effects)
• Coronary Disease (surgery)
• Ethanolamines (pharmacology)
• Female
• Heart Rate (drug effects)
• Hemodynamics (drug effects)
• Humans
• Infusions, Parenteral
• Labetalol (administration & dosage, pharmacology)
• Male
• Middle Aged
• Myocardial Revascularization
• Myocardium (metabolism)
• Oxygen Consumption (drug effects)