[Activity of oxidative enzymes of the tricarboxylic acid cycle in the liver of rats during hypokinesia].

Abstract

The activity of oxidative enzymes of the Krebs cycle was examined in white rats during hypokinesia. On hypokinesia day 7 the cytosol activity of NAD-dependent isocitrate dehydrogenase (ICDH) increased and that of malic-enzyme decreased. On hypokinesia days 30 and 45 the activity of succinate dehydrogenase (SDH) and alpha-ketoglutarate dehydrogenase (alpha-KGDH) decreased, that of cytoplasmatic malate dehydrogenases (MDH) slightly increased, and that of NADP ICDH declined. On hypokinesia day 60 the total activity of mitochondrial dehydrogenases reduced due to a low protein content of the mitochondrial fraction, whereas the specific activity either remained unchanged (ICDH, NAD MDH, alpha-KGDH) or increased (SDH, NADP MDH). On recovery day 25 only the activity of mitochondrial NAD-dependent malate and isocitrate dehydrogenases returned to normal.

• Authors: Iu A Ganin
• Journal: Kosmicheskaia biologiia i aviakosmicheskaia meditsina (Kosm Biol Aviakosm Med) Vol. 17 Issue 1 Pg. 67-71 ( 1983) ISSN: 0321-5040 [Print] Russia (Federation)
• Vernacular Title: Aktivnost' okislitel'nykh fermentov tsikla trikarbonovykh kislot v pecheni krys pri gipokinezii.
• PMID: 6843075 (Publication Type: English Abstract, Journal Article)

Chemical References

• Malate Dehydrogenase
• Isocitrate Dehydrogenase
• Ketoglutarate Dehydrogenase Complex
• Succinate Dehydrogenase

Topics

• Animals
• Citric Acid Cycle
• Cytosol (enzymology)
• Isocitrate Dehydrogenase (metabolism)
• Ketoglutarate Dehydrogenase Complex (metabolism)
• Liver (ultrastructure)
• Malate Dehydrogenase (metabolism)
• Male
• Mitochondria, Liver (enzymology)
• Rats
• Restraint, Physical
• Succinate Dehydrogenase (metabolism)