Activation of macrophages by quinonyl-N-acetylmuramyl dipeptide.

The effect of 6-O-QS-10-N-acetylmuramyl-L-valyl-D-isoglutamine methyl ester (quinonyl-MDP-66) on various functions of macrophages was examined. Mouse peritoneal macrophages, when treated either in vitro or in vivo with quinonyl-MDP-66 suspended in phosphate-buffered saline, showed a capacity for cytolysis and cytostasis against tumor targets and released H2O2 in the presence of phorbol myristate acetate. The macrophages induced by quinonyl-MDP-66 also had both antibody-dependent cell-mediated cytotoxicity and phagocytic activity against erythroid targets. The fact that synthetic quinonyl-MDP-66 stimulates the macrophages to become more cytotoxic than do other MDP analogs suggests that the lipophilic residue (QS-10) in quinonyl-MDP-66 may be important for the development of this activity.
AuthorsI Saiki, Y Tokushima, K Nishimura, Y Yamamura, I Azuma
JournalInfection and immunity (Infect Immun) Vol. 40 Issue 2 Pg. 622-8 (May 1983) ISSN: 0019-9567 [Print] United States
PMID6840857 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Acetylmuramyl-Alanyl-Isoglutamine
  • quinonyl-MDP-66
  • Hydrogen Peroxide
  • Acetylmuramyl-Alanyl-Isoglutamine (analogs & derivatives, immunology, pharmacology)
  • Animals
  • Antibody-Dependent Cell Cytotoxicity (drug effects)
  • Cells, Cultured
  • Cytotoxicity, Immunologic (drug effects)
  • Female
  • Hydrogen Peroxide (biosynthesis)
  • Macrophage Activation
  • Macrophages (immunology)
  • Mice
  • Phagocytosis (drug effects)

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