Abstract |
In order to study the biological nature of various mammary tumors, differences in the formation of polynuclear cells after the administration of cytochalasin B were investigated in cultures of human mammary tumors and normal mammary gland. When cytochalasin B was applied to the cultures, polynuclear cells increased in all cancer cases (6.1% on average), but relatively little effect was seen in cases of benign tumors and normal mammary gland (less than 1.1% on average). From these results, it appears that the difference in polynucleation on treatment with cytochalasin B may be useful as a biological means to distinguish human malignant and benign mammary tumors.
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Authors | T Asaga, K Suzuki, S Takemiya, T Okamoto, N Tamura, M Umeda |
Journal | Gan
(Gan)
Vol. 74
Issue 1
Pg. 95-9
(Feb 1983)
ISSN: 0016-450X [Print] Japan |
PMID | 6840441
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Breast
(ultrastructure)
- Breast Neoplasms
(ultrastructure)
- Cell Nucleus
(drug effects)
- Cells, Cultured
- Cytochalasin B
(pharmacology)
- Female
- Fibrocystic Breast Disease
(pathology)
- Humans
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