T-antigen does not induce cell mediated immunity in patients with breast cancer.

Abstract

A total of 80 subjects with benign and malignant breast disease and healthy controls were studied for reactivity to T-antigen, MN-antigens and phytohemagglutinin (PHA) using the lymphocyte blastogenesis assay. No differences were detected between controls and patients with benign or malignant breast disease in reactivity to T- and MN-antigens. Moreover, there was no differential response to T- and MN-antigens among patients with breast cancer. PHA reactivity, although similar between groups as a whole, was diminished in patients with advanced carcinoma. These findings indicate that T-antigen fails to induce cell mediated immunity in patients with breast cancer.

• Authors: D R Howard
• Journal: Cancer (Cancer) Vol. 51 Issue 11 Pg. 2053-6 (Jun 01 1983) ISSN: 0008-543X [Print] United States
• PMID: 6839295 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Antigens, Neoplasm
• MNSs Blood-Group System
• Phytohemagglutinins

Topics

• Adult
• Antigens, Neoplasm (immunology)
• Breast Neoplasms (immunology)
• Female
• Humans
• Immunity, Cellular
• Lymphocyte Activation
• MNSs Blood-Group System (immunology)
• Middle Aged
• Phytohemagglutinins (pharmacology)