[Karyotype of peripheral blood lymphocytes in patients treated for Hodgkin disease].
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| Abstract |
Peripheral lymphocyte chromosomes were analyzed in 55 consecutive patients with complete remission after treatment for Hodgkin's disease. In 8 patients, observed metaphases were too few in number. The other 47 patients, 29 men and 18 women, had been off all therapy for 53 months (median 41, ext. 1 to 250 months). The mean interval since the diagnosis was 78 months (median: 73 months) and the mean age at the time of chromosome analysis was 38 years (median: 34, ext. 10-78 years). No patient had either a preleukemic syndrome or leukemia. In contrast to karyotypes in normal controls and previously untreated patients, abnormal cells, hypodiploid, hyperdiploid and tetradiploid cells were more frequent. But neither monosomy 5 or 7 nor trisomy 8 were observed. Intrachromosomal rearrangements (gaps, breaks...) were significantly more frequent (12% vs 5% in untreated patients) particularly on chromosomes 1 and 2. Interchromosomal rearrangements were also numerous (1,25%) but no cells showed any specific translocation for malignant hemopathy. Chromosomal aberrations do not seem closely associated with treatments but influenced by the post-diagnosis interval and the factors present at the time of primary treatment.
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| Authors | P Cappelaere, J L Lai, A Caty, M Deminatti, M C Demaille |
| Journal | Bulletin du cancer (Bull Cancer) Vol. 70 Issue 1 Pg. 31-9 ( 1983) ISSN: 0007-4551 [Print] France |
| Vernacular Title | Le caryotype des lymphocytes sanguins périphériques des hodgkiniens traités. |
| PMID | 6839032 (Publication Type: English Abstract, Journal Article) |
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