Liposomal blockade of the reticuloendothelial system: improved tumor imaging with small unilamellar vesicles.

Abstract

The reticuloendothelial system of mice bearing EMT6 tumors was effectively blocked by intravenous injections of small unilamellar vesicles that incorporated a 6-aminomannose derivative of cholesterol in the lipid bilayer. Neutral liposomes loaded with indium-111-nitrilotriacetic acid were then injected. Fifty percent more radioactivity was deposited in tumors of the animals with blocked reticuloendothelial systems than in controls. Twenty-four hours after the injection of radioactive vesicles, well-defined tumor images were observed in whole-body gamma camera scintigraphs. Biodistribution studies showed that tumors from animals with blocked reticuloendothelial systems had more than twice the radioactivity per gram than any other tissue analyzed.

• Authors: R T Proffitt, L E Williams, C A Presant, G W Tin, J A Uliana, R C Gamble, J D Baldeschwieler
• Journal: Science (New York, N.Y.) (Science) Vol. 220 Issue 4596 Pg. 502-5 (Apr 29 1983) ISSN: 0036-8075 [Print] United States
• PMID: 6836294 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Liposomes
• Radioisotopes
• Indium
• Nitrilotriacetic Acid

Topics

• Animals
• Indium
• Liposomes (administration & dosage)
• Male
• Mice
• Mice, Inbred BALB C
• Mononuclear Phagocyte System (physiopathology)
• Neoplasm Transplantation
• Neoplasms (diagnostic imaging)
• Neoplasms, Experimental (diagnostic imaging)
• Nitrilotriacetic Acid
• Radioisotopes
• Radionuclide Imaging (methods)