Immunostimulation with muramyl dipeptide and its desmethyl analogue: Studies of non-specific resistance to pulmonary blastomycosis in inbred mouse strains.

Abstract

N-acetyl-muramyl-L-alanyl-D-isoglutamine (MDP) protected against pulmonary blastomycosis when given prophylactically to BALB/c mice. Its desmethyl analogue (DM-MDP) had a similar effect. In C3H/HeJ, the effect was less marked. Early treatment after infection, with MDP and DM-MDP, had a modest effect in C3H/HeJ and BALB/c respectively, whereas late treatment had no effect in any mouse strain. No effect could be demonstrated with challenge sizes producing too lethal a model or minimal lethality, or in DBA/2J or young BALB/c mice. The effects in various strains do not correlate with differing effects on nonspecific immunostimulation in these strains. Immunostimulation with glycopeptides deserves further study in prophylaxis or therapy of fungal infection.

• Authors: P A Morozumi, E Brummer, D A Stevens
• Journal: Mycopathologia (Mycopathologia) Vol. 81 Issue 1 Pg. 35-9 (Jan 17 1983) ISSN: 0301-486X [Print] Netherlands
• PMID: 6835353 (Publication Type: Journal Article)

Chemical References

• Acetylmuramyl-Alanyl-Isoglutamine
• N-acetyl-demethylmuramyl-alanyl-isoglutamine

Topics

• Acetylmuramyl-Alanyl-Isoglutamine (analogs & derivatives, immunology)
• Animals
• Blastomycosis (immunology)
• Immunization
• Lung Diseases, Fungal (immunology)
• Mice
• Mice, Inbred BALB C (immunology)
• Mice, Inbred C3H (immunology)
• Mice, Inbred DBA (immunology)
• Mice, Inbred Strains (immunology)