Pellagra probably due to pyrazinamide: development during combined chemotherapy of tuberculosis.

Abstract	Pellagra secondary to antituberculous chemotherapy can result from isoniazide therapy, as well as from pyrazinamide treatment. Because of the similarity in structural formulas between pyrazinamide, isoniazide, and nicotinamide, the substrate competition is the mechanism most likely involved. The patient was cured by administration of nicotinamide during continued unchanged chemotherapy of her tuberculosis.
Authors	J Jørgensen
Journal	International journal of dermatology (Int J Dermatol) 1983 Jan-Feb Vol. 22 Issue 1 Pg. 44-5 ISSN: 0011-9059 [Print] England
PMID	6832880 (Publication Type: Case Reports, Journal Article)
Chemical References	Antitubercular Agents Pyrazinamide Isoniazid
Topics	Adult Antitubercular Agents (therapeutic use) Chemical Phenomena Chemistry Drug Therapy, Combination Female Humans Isoniazid (administration & dosage, adverse effects) Pellagra (chemically induced) Pyrazinamide (administration & dosage, adverse effects) Tuberculosis, Pulmonary (drug therapy)

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