Abstract |
In the present paper, two experiments are performed to test the efficacy of the intravenous administration of hypertonic glucose (25 or 50%) in alcoholic intoxication. In a first experiment, 10 healthy, nonstarved volunteers, received 15 min after the ingestion of 1.0 g/kg alcohol, 40 ml of 25% glucose i.v., the same volume of 0.9% NaCl or no injection. According to evaluations performed at several time intervals up to 2 h after alcohol ingestion, no difference among the 3 conditions was observed either in the intensity of alcohol intoxication or on blood alcohol levels. In a second experiment, blood glucose and alcohol levels were evaluated in 80 alcoholized patients in an emergency room. The mean glycemic value was 94 mg/100 ml. No difference was found by comparing this value with that presented by nonalcoholized patients. The 80 patients were distributed in two groups of 40 each: one of them was intravenously administered 40 ml of glucose 50% while the other was injected with saline. About 20-30 min later the patients of both groups were clinically evaluated by the physician on duty, being considered equally improved regardless of the injection. The self-evaluation by the patients provided similar results.
|
Authors | J Masur, M L de Souza, R R Laranjeira, A P Zwicker, G G Formigoni |
Journal | Pharmacology
(Pharmacology)
Vol. 26
Issue 1
Pg. 54-60
( 1983)
ISSN: 0031-7012 [Print] Switzerland |
PMID | 6828550
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Blood Glucose
- Glucose Solution, Hypertonic
- Ethanol
- Glucose
|
Topics |
- Adult
- Alcoholic Intoxication
(drug therapy)
- Blood Glucose
(metabolism)
- Emergency Service, Hospital
- Ethanol
(blood)
- Female
- Glucose
(therapeutic use)
- Glucose Solution, Hypertonic
(therapeutic use)
- Humans
- Injections, Intravenous
- Male
- Time Factors
|