Abstract |
Treatment of CBA/Ca mice with cortisone acetate for a short period after infection with Trichuris muris induces a state of immunotolerance which allows the development and survival of a chronic infection. Mice harbouring such infections were found to be less capable of responding to a primary infection with Trichinella spiralis or of producing humoral responses to lipopolysaccharide and sheep red blood cells. Mesenteric lymph node T cells, however, were as responsive to the polyclonal activator phytohaemagglutinin as those from normal mice. Homing to the intestinal tract of activated mesenteric lymph node cells from helminth-infected donors was not impaired in the animals harbouring chronic infections. The results are discussed in terms of antigenic competition and with respect to their relevance to chronic human trichuriasis.
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Authors | T D Lee, D Wakelin |
Journal | Immunology
(Immunology)
Vol. 48
Issue 3
Pg. 571-7
(Mar 1983)
ISSN: 0019-2805 [Print] England |
PMID | 6826206
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Phytohemagglutinins
- Cortisone
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Topics |
- Animals
- Antibody Formation
- Chronic Disease
- Cortisone
(analogs & derivatives, pharmacology)
- Disease Models, Animal
- Immune Tolerance
(drug effects)
- Intestines
(immunology)
- Lymphocyte Activation
- Lymphocytes
(physiology)
- Male
- Mice
- Mice, Inbred CBA
- Phytohemagglutinins
(pharmacology)
- Trichinellosis
(immunology)
- Trichuriasis
(immunology)
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