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The effect of native and single stranded DNA on the platelet release reaction. Enhancement of aggregated IgG-induced serotonin release.

Abstract
Native (n) but not single stranded (ss) DNA was found to induce release of 3H-serotonin (5-HT) from platelets of the majority of normal individuals. However, ssDNA markedly enhanced 5-HT release induced by heat-aggregated IgG (aggIgG), while less enhancement was seen using nDNA. Similar enhancement was produced by polyinosinic acid but not by polyinosinic:polycytidylic acid. The ability of ssDNA to potentiate aggIgG-induced 5-HT release seemed specific for aggIgG, since no effect on ADP or epinephrine-induced release was observed and thrombin-induced release was inhibited. In contrast, nDNA in high concentrations (100 micrograms/ml) potentiated ADP, epinephrine, and thrombin-induced 5-HT release. These results suggest that ss-and nDNA may interact with platelets by different mechanisms and provide a means by which DNA, released at sites of tissue injury, could modulate the role of platelets in the inflammatory response. The ability of DNA to enhance the aggIgG-induced platelet release reaction may be important in immune complex diseases such as systemic lupus erythematosus.
AuthorsC A Dorsch, J Killmayer
JournalArthritis and rheumatism (Arthritis Rheum) Vol. 26 Issue 2 Pg. 179-85 (Feb 1983) ISSN: 0004-3591 [Print] United States
PMID6824515 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • DNA, Single-Stranded
  • Immunoglobulin G
  • Poly I
  • Serotonin
  • Adenosine Diphosphate
  • DNA
  • Thrombin
  • Poly I-C
  • Imipramine
  • Epinephrine
Topics
  • Adenosine Diphosphate (pharmacology)
  • Blood Platelets (metabolism)
  • DNA (pharmacology)
  • DNA, Single-Stranded (pharmacology)
  • Epinephrine (pharmacology)
  • Humans
  • Imipramine (pharmacology)
  • Immunoglobulin G (physiology)
  • Poly I (pharmacology)
  • Poly I-C (pharmacology)
  • Serotonin (metabolism)
  • Thrombin (pharmacology)

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