Paradoxical anti-leukemic effects of plant-derived tumor promoters on a human thymic lymphoblast cell line.

Abstract

Three different diterpen polyols and the teleocidin have antileukemic effects on the human thymic leukemia cell line HPB-ALL by inducing phenotypic differentiation. We tested TPA (phorbol esters), mezerein (daphnane), milliamin (ingenol ester) and teleocidin B (teleocidins) as representative of the chemical structure of each principle and found that these agents have the similar biological activity of inducing phenotypic differentiation in HPB-ALL cells. Moreover, competitive binding of [3H]PDB to cell-surface receptors was significantly inhibited by these agents; n-butyrate and phorbol per se did not inhibit the binding of [3H]PDB. Despite differences in the structure of the principles, these agents may have similarly acting side-chain structures.

• Authors: Y Nakao, S Matsuda, H Kimoto, T Matsui, N Kobayashi, M Kishihara, T Fujita, S Watanabe, K Ueda, Y Ito
• Journal: International journal of cancer (Int J Cancer) Vol. 30 Issue 6 Pg. 687-95 (Dec 15 1982) ISSN: 0020-7136 [Print] United States
• PMID: 6819241 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Alkaloids
• Antigens, Surface
• Carcinogens
• Diterpenes
• Lyngbya Toxins
• Phorbol Esters
• Terpenes
• Poly Adenosine Diphosphate Ribose
• teleocidins
• mezerein
• Phorbol 12,13-Dibutyrate
• DNA

Topics

• Alkaloids (pharmacology)
• Antigens, Surface (analysis)
• Carcinogens (pharmacology)
• Cell Differentiation (drug effects)
• Cell Division (drug effects)
• Cell Line
• DNA (biosynthesis)
• Diterpenes (pharmacology)
• Fluorescent Antibody Technique
• Humans
• Leukemia, Lymphoid (metabolism, pathology)
• Lyngbya Toxins
• Phorbol 12,13-Dibutyrate
• Phorbol Esters (metabolism, pharmacology)
• Poly Adenosine Diphosphate Ribose (metabolism)
• Rosette Formation
• T-Lymphocytes
• Terpenes