[Reduction of platelet serotonin in major depression (endogenous depression)].

Abstract

Serum serotonin (5-HT) levels were measured in several patients with psychiatric disorders using high pressure liquid chromatography with electrochemical detection. A marked reduction in 5-HT levels was found in male and female patients with major depressive disorder, as compared to controls, but not in dysthymic disorder. These modifications may constitute biochemical changes suggestive of major depressive disorders; they could not be attributed to chronic antidepressant treatment.

• Authors: H L Kim, O Plaisant, M Leboyer, C Gay, L Kamal, M A Devynck, P Meyer
• Journal: Comptes rendus des seances de l'Academie des sciences. Serie III, Sciences de la vie (C R Seances Acad Sci III) Vol. 295 Issue 10 Pg. 619-22 (Nov 22 1982) ISSN: 0249-6313 [Print] France
• Vernacular Title: Diminution de la sérotonine plaquettaire dans la dépression majeure (dépression endogène).
• PMID: 6819060 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Serotonin

Topics

• Adult
• Aged
• Blood Platelets (metabolism)
• Chromatography, High Pressure Liquid
• Depressive Disorder (blood)
• Female
• Humans
• Male
• Middle Aged
• Paranoid Disorders (blood)
• Reference Values
• Schizophrenia (blood)
• Serotonin (blood)
• Sex Factors