HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Administration of iduronate sulfatase by plasma exchange to patients with the Hunter syndrome: a clinical study.

Abstract
The Hunter syndrome (MPS II) is the only mucopolysaccharidosis in which there is appreciable activity of the deficient enzyme in normal plasma. We performed enzyme-replacement treatment by plasma exchange in five Hunter syndrome children. Carefully monitoring the cardiovascular status, we administered monthly single plasma volume exchanges for a 3 to 8 mo period. The results indicate a substantial gain of enzyme activity, persisting with a t50% = 19 +/- 5 hr. The maximal level and persistence of increased enzyme activity did not change after repeated exchanges, suggesting that immune responses were not elicited. Despite this, no demonstrable clinical benefit was apparent when the study group was compared with an age-matched control group of Hunter syndrome patients.
AuthorsF R Brown 3rd, C W Hall, E F Neufeld, L L Munoz, H Braine, S Andrzejewski, E E Camargo, S A Mark, J M Richard, H W Moser
JournalAmerican journal of medical genetics (Am J Med Genet) Vol. 13 Issue 3 Pg. 309-18 (Nov 1982) ISSN: 0148-7299 [Print] United States
PMID6817638 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Sulfatases
  • Iduronate Sulfatase
Topics
  • Adolescent
  • Child
  • Child, Preschool
  • Growth
  • Humans
  • Iduronate Sulfatase (administration & dosage)
  • Intelligence
  • Mucopolysaccharidosis II (diagnosis, therapy)
  • Plasma Exchange
  • Sulfatases (administration & dosage)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: