Immunological studies with sulpholipids of mycobacteria.

Abstract

Antibodies to sulpholipids of mycobacteria were produced in rabbits when injected as sulpholipid-MBSA complexes and were detected by kaolin agglutination and double diffusion techniques. Sulpholipid antibodies did not cross react with any other lipids of mycobacteria except cord-factor. The antigenicity of sulpholipids appears to be due to alpha-D-trehalose and sulphate groups. Guinea pigs immunized with sulpholipid-MBSA complexes showed partial protection against tuberculous infection with M. tuberculosis H37Rv, as revealed by mortality rate and score of lesions.

• Authors: G K Khuller, U Malik, D Subrahmanyam
• Journal: Tubercle (Tubercle) Vol. 63 Issue 2 Pg. 107-11 (Jun 1982) ISSN: 0041-3879 [Print] Scotland
• PMID: 6817483 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antibodies, Bacterial
• Antigens, Bacterial
• Lipids
• sulfolipids

Topics

• Animals
• Antibodies, Bacterial (immunology)
• Antigen-Antibody Reactions
• Antigens, Bacterial (immunology)
• Cross Reactions
• Guinea Pigs
• Immunization
• Lipids (immunology)
• Mycobacteriaceae (immunology)
• Mycobacterium bovis (immunology)
• Mycobacterium phlei (immunology)
• Mycobacterium tuberculosis (immunology)
• Tuberculosis (prevention & control)