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Tay-Sachs disease and normal cerebellar cells in culture: elevated levels of lysosomal enzymes in Tay-Sachs disease cells.

Abstract
Tay-Sachs disease and normal fetal cerebellar cells were maintained in culture for up to four weeks. Elevated levels of the lysosomal enzymes hexosaminidase B, beta-galactosidase, and acid phosphatase were observed in the Tay-Sachs cells in long term cultures although elevated lysosomal enzyme levels were not observed in the normal cultures. Similarly, elevated lysosomal enzyme activities were observed in Tay-Sachs cultures which had been treated with Concanavalin A.
AuthorsL M Hoffman, S E Brooks, L Schneck
JournalJournal of neuroscience research (J Neurosci Res) Vol. 8 Issue 1 Pg. 49-55 ( 1982) ISSN: 0360-4012 [Print] United States
PMID6816949 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Hydrolases
  • Acid Phosphatase
  • Hexosaminidases
  • beta-Galactosidase
Topics
  • Acid Phosphatase (metabolism)
  • Cells, Cultured
  • Cerebellum (enzymology)
  • Female
  • Fetus
  • Hexosaminidases (metabolism)
  • Humans
  • Hydrolases (metabolism)
  • Kinetics
  • Lysosomes (enzymology)
  • Pregnancy
  • Reference Values
  • Tay-Sachs Disease (enzymology)
  • beta-Galactosidase (metabolism)

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