Abstract |
An immunoproliferative disorder with M component IgD/lambda and a strong decrease of the other Ig classes in the serum is reported. The peculiarity of this disorder consists in the shift from a predominant chronic lymphocytic leukaemic pattern, at the beginning, to a true myeloma with plasmacytic leukaemia IgD/lambda several months later. The possibility of the removal, in this case, of the initial precocious block with derepression or 'switch on' in transformation of the malignant lymphocyte clone and, consequently, change of a type of malignant lymphoma into another more evoluted and more malignant type is discussed.
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Authors | G Buchi, G Palestro, E Leonardo, G Termine, R Autino |
Journal | Acta haematologica
(Acta Haematol)
Vol. 68
Issue 2
Pg. 105-8
( 1982)
ISSN: 0001-5792 [Print] Switzerland |
PMID | 6812364
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Immunoglobulin D
- Immunoglobulin lambda-Chains
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Topics |
- B-Lymphocytes
(immunology)
- Humans
- Immunoglobulin D
(biosynthesis)
- Immunoglobulin lambda-Chains
(biosynthesis)
- Leukemia, Lymphoid
(complications, immunology)
- Leukemia, Plasma Cell
(etiology, immunology, mortality)
- Lymphocyte Activation
- Lymphoproliferative Disorders
(immunology)
- Male
- Middle Aged
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