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Vitamin C in the control of hypercholesterolemia in man.

Abstract
The activity of the cholesterol 7 alpha-hydroxylating system containing cyto-chrome P-450 is depressed in the liver of guinea-pigs with chronic marginal vitamin C deficiency. Slowing-down of this rate-limiting reaction of cholesterol transformation to bile acids causes cholesterol accumulation in the liver, blood plasma and arteries, increase in the index total: HDL cholesterol, prolongation of plasma cholesterol half-life, increase in the index cholesterol: bile acids in the gall-bladder bile, cholesterol gallstone formation and atheromatous changes on coronary arteries in guinea-pigs with long-lasting marginal vitamin C deficiency. The most effective means for preventing these changes are vitamin C doses ensuring maximal steady-state levels of ascorbate in the tissues. In most of hypercholesterolemic persons with a low vitamin C status, the administration of ascorbic acid in doses 500-1000 mg per day lowers total cholesterol concentration in blood plasma. This effect may be reinforced through a simultaneous administration of bile acids sequestrants, such as cholestyramine or pectin. In every form of hypercholesterolemia therapy (dietary and/or pharmacological), an adequate vitamin C supply should be ensured in doses capable of creating maximal steady-state levels of ascorbate in human tissues.
AuthorsE Ginter, P Bobek, F Kubec, J Vozár, D Urbanová
JournalInternational journal for vitamin and nutrition research. Supplement = Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Supplement (Int J Vitam Nutr Res Suppl) Vol. 23 Pg. 137-52 ( 1982) Canada
PMID6811477 (Publication Type: Journal Article)
Chemical References
  • Pectins
  • Cholesterol
  • Ascorbic Acid
Topics
  • Ascorbic Acid (physiology, therapeutic use)
  • Ascorbic Acid Deficiency (blood)
  • Cholesterol (metabolism)
  • Drug Synergism
  • Humans
  • Hypercholesterolemia (drug therapy)
  • Pectins (pharmacology)
  • Spleen (metabolism)
  • Time Factors

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