Fish oil feeding lowers thromboxane- and prostacyclin production by rat platelets and aorta and does not result in the formation of prostaglandin I3.

Abstract	It is demonstrated that feeding cod-liver oil to rats leads to a considerable reduction in the formation of platelet TxA2 and of vascular PGI2. No appreciable formation of TxA3 and PGI3 is observed, although arterial thrombosis is depressed and bleeding time is prolonged. These findings contradict the suggested role of prostaglandins of the 3-series in thromboregulation.
Authors	G Hornstra, E Christ-Hazelhof, E Haddeman, F ten Hoor, D H Nugteren
Journal	Prostaglandins (Prostaglandins) Vol. 21 Issue 5 Pg. 727-38 (May 1981) ISSN: 0090-6980 [Print] United States
PMID	6803303 (Publication Type: Journal Article)
Chemical References	Fish Oils Oils Prostaglandins Thromboxanes Thromboxane A2 prostaglandin I3 Cod Liver Oil Epoprostenol Lipoxygenase Prostaglandin-Endoperoxide Synthases
Topics	Animals Blood Platelets (drug effects, metabolism) Cod Liver Oil (pharmacology) Diet Epoprostenol (biosynthesis) Fish Oils (pharmacology) Helianthus Lipoxygenase (metabolism) Male Muscle, Smooth, Vascular (drug effects, metabolism) Oils (pharmacology) Prostaglandin-Endoperoxide Synthases (metabolism) Prostaglandins (biosynthesis) Rats Rats, Inbred Strains Thromboxane A2 (biosynthesis) Thromboxanes (biosynthesis)

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