HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Effects of sex steroids on the development of 7,12-dimethylbenz[a]anthracene-induced mammary dysplasia in neonatally androgenized female rats.

Abstract
The development of mammary dysplasia (mastopathia cystica) induced by 7,12-dimethylbenz[a]anthracene (DMBA) in neonatally androgenized female rats was dependent on estrogens, and cystic-type mammary dysplasia developed in rats with a relative or absolute excess of estrogens. At 2 days of age, 137 female rats were neonatally androgenized by single subcutaneous injections of 1.25 mg testosterone propionate (TP). At 50 days of age, all rats were given 20 mg DMBA by gastric intubation. About one-half of the TP rats were ovariectomized at 78 days of age. Rats in test groups were given daily intramuscular injections of 10 micrograms 17 beta-estradiol (E) or 4 mg progesterone (P) for 228 days starting from 78 days after birth. In all TP rats, corpora lutea were absent in the ovaries. the incidence of mammary dysplasia in TP rats was 89.7%. Ovariectomy (OVEX) of TP rats induced a significant and marked decrease in the incidence of mammary dysplasia (3.7%). In TP rats with OVEX, a high incidence of mammary dysplasia was found in those given E (95.7%) but not in those given P (0%). The incidences of cystic-type mammary dysplasia in TP rats, TP rats with E, TP rats with OVEX and E and TP rats with P were 65.5, 86.7, 91.3 and 0%, respectively.
AuthorsH Yoshida, R Fukunishi
JournalGan (Gan) Vol. 72 Issue 2 Pg. 315-7 (Apr 1981) ISSN: 0016-450X [Print] Japan
PMID6793442 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Benz(a)Anthracenes
  • Testosterone
  • Progesterone
  • Estradiol
  • 9,10-Dimethyl-1,2-benzanthracene
Topics
  • 9,10-Dimethyl-1,2-benzanthracene
  • Animals
  • Benz(a)Anthracenes
  • Breast Diseases (chemically induced)
  • Castration
  • Estradiol (pharmacology)
  • Female
  • Fibrocystic Breast Disease (chemically induced)
  • Progesterone (pharmacology)
  • Rats
  • Testosterone (pharmacology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: