[Prophylaxis of recurrent urinary infections in children. Long-term use of a weak dose of trimethoprim-sulfamethoxazole].

Abstract

The efficacy of a long-term prophylaxis with Co-trimoxazole was studied in 18 girls with recurrent urinary tract infections. SEven patients had neither anatomical nor functional anomalies of the urinary tract. Eight patients had a vesico-ureteral reflux, and three patients a complex urinary problem. The following therapeutic plan was applied: administration of a low dose of Co-trimoxazole (TMP: 0,6-1 mg/kg) given as a single evening dose during 3 months followed by a 3-month period without treatment. The children were followed in this way during 2 years. Seven children had no reinfection from the start of the prophylaxis during the 2 years of observation. Nine children had a significant decrease of the number of reinfections during the Co-trimoxazole treatment periods. Two children without anatomical anomaly had early reinfections with Co-trimoxazole resistant germs. No side effects related to Co-trimoxazole have been observed, and the tolerance of treatment was excellent. Co-trimoxazole administered as a single evening low dose efficiently prevented the recurrence of urinary tract infections.

• Authors: P Schläppy, L Paunier, A Cuendet
• Journal: Helvetica paediatrica acta (Helv Paediatr Acta) Vol. 36 Issue 3 Pg. 241-8 (Jul 1981) ISSN: 0018-022X [Print] Switzerland
• Vernacular Title: Prophylaxie des infections urinaires récidivantes de l'enfant. Emploi à long terme d'une faible dose de Trimethoprim-Sulfamethoxazole.
• PMID: 6792161 (Publication Type: English Abstract, Journal Article)

Chemical References

• Drug Combinations
• Sulfadiazine
• sulfadiazine, trimethoprim drug combination
• Trimethoprim

Topics

• Adolescent
• Child
• Child, Preschool
• Dose-Response Relationship, Drug
• Drug Combinations (therapeutic use)
• Female
• Humans
• Long-Term Care
• Recurrence
• Sulfadiazine (therapeutic use)
• Trimethoprim (therapeutic use)
• Urinary Tract Infections (drug therapy)