Serum glutamate dehydrogenase as a marker of hepatocyte necrosis in alcoholic liver disease.

Abstract

Serum glutamate dehydrogenase concentration was assessed as a marker of the degree of hepatocyte necrosis found at liver biopsy in 95 patients suspected of having alcoholic liver disease. Although the serum concentration was raised in 54 patients, no relation between it and the severity of hepatocyte necrosis could be established. Glutamate dehydrogenase was therefore not confirmed to be a useful indicator of hepatocyte necrosis in patients with chronic alcoholism.

• Authors: P R Mills, R J Spooner, R I Russell, P Boyle, R N MacSween
• Journal: British medical journal (Clinical research ed.) (Br Med J (Clin Res Ed)) Vol. 283 Issue 6294 Pg. 754-5 (Sep 19 1981) ISSN: 0267-0623 [Print] England
• PMID: 6791735 (Publication Type: Journal Article)

Chemical References

• Glutamate Dehydrogenase

Topics

• Glutamate Dehydrogenase (blood)
• Humans
• Liver (pathology)
• Liver Diseases, Alcoholic (blood, enzymology, pathology)
• Necrosis