Facilitation of shock-induced fighting following intraventricular 5,7-dihydroxytryptamine and 6-hydroxydopa.

Abstract

Using a 15-s intershock interval, an increase in shock-induced fighting was observed following intraventricular 96 microgram 5,7-dihydroxytryptamine (5,7-DHT) and 90 microgram 6-hydroxydopa (6-OHdopa). The incidence of predatory mouse killing was enhanced by 5,7-DHT, but was not affected by 6-OHdopa. Pain sensitivity was increased by 6-OHdopa, but both neurotoxins produced hyperreactivity to footshock. Specific serotonin depletion was produced by 5,7-DHT and norepinephrine depletion by 6-OHdopa. The increase in shock-induced fighting could not be predicted on the basis of monoamine depletion alone, since a long intershock interval was necessary to observe this increase.

• Authors: K M Kantak, L R Hegstrand, B Eichelman
• Journal: Psychopharmacology (Psychopharmacology (Berl)) Vol. 74 Issue 2 Pg. 157-60 ( 1981) ISSN: 0033-3158 [Print] Germany
• PMID: 6791220 (Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Analgesics
• Biogenic Amines
• Dihydroxytryptamines
• 6-hydroxydopa
• 5,7-Dihydroxytryptamine
• Dihydroxyphenylalanine

Topics

• 5,7-Dihydroxytryptamine (pharmacology)
• Aggression (drug effects)
• Analgesics
• Animals
• Biogenic Amines (metabolism)
• Brain Chemistry (drug effects)
• Dihydroxyphenylalanine (analogs & derivatives, pharmacology)
• Dihydroxytryptamines (pharmacology)
• Electroshock
• Humans
• Injections, Intraventricular
• Male
• Rats
• Stimulation, Chemical