In vitro activity of 2-alkyl-3-hydroxy-1,4-naphthoquinones against Theileria parva.

Abstract

A variety of naphthoquinones have veen prepared and evaluated in vitro against the causative agent of the cattle disease East Coast Fever-Theileria parva infection. It is concluded from structure-activity studies that a 2-hydroxyl moiety es essential for high activity. The most active compounds tested were 2-hydroxy-3-alkyl-1,4-naphthoquinones in which the alkyl moiety was cyclohexyl, cyclohexylcyclohexyl, tridecyl, or tetradecyl.

• Authors: P Boehm, K Cooper, A T Hudson, J P Elphick, N McHardy
• Journal: Journal of medicinal chemistry (J Med Chem) Vol. 24 Issue 3 Pg. 295-9 (Mar 1981) ISSN: 0022-2623 [Print] United States
• PMID: 6790703 (Publication Type: Journal Article)

Chemical References

• Antiprotozoal Agents
• Naphthoquinones

Topics

• Animals
• Antiprotozoal Agents (chemical synthesis, pharmacology)
• Apicomplexa (drug effects)
• Cattle
• Naphthoquinones (chemical synthesis, pharmacology)
• Structure-Activity Relationship
• Theileriasis (parasitology)