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N-Nitroso-N-methylurea elicits mammary cancer in resistant and sensitive rat strains.

Abstract
A single intravenous (i.v.) injection of the water-soluble mammary carcinogen N-nitroso-N-methylurea (NMU; 35 mg/kg of body weight) elicited cancer of the breast in young female rats of two strains in the following incidence: Long-Evans strain, 4%; Sprague-Dawley strain, 70%. In sisters of these rats, a set of 5 i.v. injections of NMU (35 mg/kg at biweekly intervals) evoked mammary carcinoma as follows: Long-Evans strain, 76%; Sprague-Dawley strain, 100%. In its effectiveness in evoking mammary cancer in Sprague-Dawley rats, the lipid-soluble mammary carcinogen 7,8,12-trimethylbenz[a]anthracene exceeded NMU in rapidity of development of cancer and in tumor yield.
AuthorsC B Huggins, N Ueda, M Wiessler
JournalProceedings of the National Academy of Sciences of the United States of America (Proc Natl Acad Sci U S A) Vol. 78 Issue 2 Pg. 1185-8 (Feb 1981) ISSN: 0027-8424 [Print] United States
PMID6785750 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Nitrosourea Compounds
  • 7,8,12-trimethylbenz(a)anthracene
  • 9,10-Dimethyl-1,2-benzanthracene
  • Methylnitrosourea
Topics
  • 9,10-Dimethyl-1,2-benzanthracene (analogs & derivatives)
  • Animals
  • Drug Resistance
  • Female
  • Mammary Neoplasms, Experimental (chemically induced, pathology)
  • Methylnitrosourea
  • Nitrosourea Compounds
  • Rats
  • Species Specificity

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