Abstract |
The effectiveness of nitroglycerin ointment in vasospastic angina pectoris at rest was evaluated in 10 patients selected for study. The study was performed after a 24 hour control period, and a randomized single-blind crossover experimental design was followed. Two percent nitroglycerin ointment (15 mg) or placebo ointment was administered every 6 hours for a period of 48 hours each; the first treatment period was followed by a second in which each preparation was used for a 24 hour period. All patients were hospitalized in the coronary care unit; an objective evaluation was carried out using a multichannel electrocardiographic recording to assure recognition of the painless ischemic episodes. Coronary angiography showed critical stenosis of one or two vessels in 9 of the 10 patients; spasm was demonstrated in 3. Results of the ergonovine test were positive in nine of nine patients. Nitroglycerin ointment produced a significant reduction in the mean daily number of episodes during the first (12.5 +/- 3.9 versus 0.5 +/- 0.4, p less than 0.02) as well as the second treatment period (10.6 +/- 3.8 versus 0.6 +/- 0.4, p less than 0.02). These results demonstrate that nitroglycerin ointment provides effective, long-lasting protection against angina due to coronary spasm.
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Authors | J A Salerno, M Previtali, A Medici, M Chimienti, E Bramucci, R Lepore, G Specchia, P Bobba |
Journal | The American journal of cardiology
(Am J Cardiol)
Vol. 47
Issue 5
Pg. 1128-33
(May 1981)
ISSN: 0002-9149 [Print] United States |
PMID | 6784566
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
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Chemical References |
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Topics |
- Adult
- Angina Pectoris
(prevention & control)
- Clinical Trials as Topic
- Coronary Angiography
- Humans
- Male
- Middle Aged
- Nitroglycerin
(administration & dosage, therapeutic use)
- Ointments
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