Prostaglandin synthetase inhibitors in the treatment of nephrogenic diabetes insipidus.

Abstract

Two boys with classical NDI have been treated with prostaglandin synthetase inhibitors. A boy, 7 years old, was treated with low solute-load diet and diuretics from his first year of life. His main complaint was nocturnal enuresis. He responded within one day to indomethacin 25 mg twice daily, and the urine volume was reduced from 4 1/2--6 litre/day to 2 1/2--3 litre/day. There is almost no enuresis. A boy, 7 months old, had a basal daily urine volume of 1.6--1.8 litre. A low solute-load diet and diuretics reduced urine volume to 1 litre, but he still needed gastric tube feeding. With the addition of acetylsalicylic acid, 75 mg three times daily, the urine volume was reduced to 600 ml, and he needed no more tube feeding. Both boys are doing well on the above-mentioned regimens, and no side effects have been observed after 1 year of treatment.

• Authors: E Monn
• Journal: Acta paediatrica Scandinavica (Acta Paediatr Scand) Vol. 70 Issue 1 Pg. 39-42 (Jan 1981) ISSN: 0001-656X [Print] Sweden
• PMID: 6782828 (Publication Type: Case Reports, Journal Article)

Chemical References

• Cyclooxygenase Inhibitors
• Hydrochlorothiazide
• Aspirin
• Indomethacin

Topics

• Aspirin (therapeutic use)
• Body Water (drug effects)
• Child
• Cyclooxygenase Inhibitors
• Diabetes Insipidus (complications, drug therapy, physiopathology)
• Humans
• Hydrochlorothiazide (therapeutic use)
• Hypernatremia (etiology)
• Indomethacin (therapeutic use)
• Infant
• Kidney (physiopathology)
• Male
• Polyuria (drug therapy)