Anticonvulsant-induced status epilepticus in Lennox-Gastaut syndrome.

Abstract

A 22-year-old woman with the Lennox-Gastaut syndrome developed serial apnoeic-tonic seizures with concomitant bursts of repetitive spikes at 16-20/sec, after receiving therapeutic doses of chlormethiazole, clonazepam, and diazepam for the treatment of serial tonic-clonic generalized seizures. There was a direct relationship between dose of chlormethiazole and frequency of apnoeic-tonic seizures. Since these tonic seizures have been noted during natural sleep and after sleep induced by various sedative drugs in patients with slow spike-wave in EEG, it is likely that the reduction in level of consciousness induced by sedative drugs is the causative factor.

• Authors: P R Bittencourt, A Richens
• Journal: Epilepsia (Epilepsia) Vol. 22 Issue 1 Pg. 129-34 (Feb 1981) ISSN: 0013-9580 [Print] United States
• PMID: 6781886 (Publication Type: Case Reports, Journal Article)

Chemical References

• Benzodiazepinones
• Drug Combinations
• Chlormethiazole
• Primidone
• Carbamazepine
• Clonazepam
• Phenytoin
• Diazepam

Topics

• Adolescent
• Adult
• Benzodiazepinones (adverse effects)
• Carbamazepine (therapeutic use)
• Child
• Child, Preschool
• Chlormethiazole (adverse effects)
• Clonazepam (adverse effects)
• Diazepam (adverse effects)
• Drug Combinations
• Electroencephalography
• Epilepsy, Absence (drug therapy)
• Female
• Humans
• Phenytoin (therapeutic use)
• Primidone (therapeutic use)
• Status Epilepticus (chemically induced, physiopathology)