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[Bioavailability of cimetidine after partial gastrectomy (author's transl)].

Abstract
Absorption characteristics of cimetidine were studied in 10 patients after Billroth I and 12 patients after Billroth II gastrectomy and compared with 9 patients without gastric disease. The onset of absorption after 400 mg cimetidine was identical in all groups, but peak plasma concentrations occurred somewhat (18%) later in B I and significantly (42%) later in B II patients (p less than 0.05). Plasma half life was not different between the 3 groups. The area under the plasma level curve as a measure for bioavailability was significantly increased in the two gastrectomy groups (17% and 23%, resp.). In addition, the duration of effective plasma concentrations above 0.5 microgram/ml was significantly prolonged in the two groups.
AuthorsR Gugler, H Wolf, G Kliems, A Somogyi
JournalMMW, Munchener medizinische Wochenschrift (MMW Munch Med Wochenschr) Vol. 122 Issue 39 Pg. 1337-40 (Sep 26 1980) ISSN: 0341-3098 [Print] Germany
Vernacular TitleBioverfügbarkeit von Cimetidin nach Magenteilresketion.
PMID6780813 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Guanidines
  • Cimetidine
Topics
  • Biological Availability
  • Cimetidine (blood, therapeutic use)
  • Duodenal Ulcer (surgery)
  • Female
  • Gastrectomy
  • Guanidines (blood)
  • Humans
  • Intestinal Absorption
  • Male
  • Middle Aged

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