Abstract |
Absorption characteristics of cimetidine were studied in 10 patients after Billroth I and 12 patients after Billroth II gastrectomy and compared with 9 patients without gastric disease. The onset of absorption after 400 mg cimetidine was identical in all groups, but peak plasma concentrations occurred somewhat (18%) later in B I and significantly (42%) later in B II patients (p less than 0.05). Plasma half life was not different between the 3 groups. The area under the plasma level curve as a measure for bioavailability was significantly increased in the two gastrectomy groups (17% and 23%, resp.). In addition, the duration of effective plasma concentrations above 0.5 microgram/ml was significantly prolonged in the two groups.
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Authors | R Gugler, H Wolf, G Kliems, A Somogyi |
Journal | MMW, Munchener medizinische Wochenschrift
(MMW Munch Med Wochenschr)
Vol. 122
Issue 39
Pg. 1337-40
(Sep 26 1980)
ISSN: 0341-3098 [Print] Germany |
Vernacular Title | Bioverfügbarkeit von Cimetidin nach Magenteilresketion. |
PMID | 6780813
(Publication Type: English Abstract, Journal Article)
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Chemical References |
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Topics |
- Biological Availability
- Cimetidine
(blood, therapeutic use)
- Duodenal Ulcer
(surgery)
- Female
- Gastrectomy
- Guanidines
(blood)
- Humans
- Intestinal Absorption
- Male
- Middle Aged
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