A bleeding disease (von Willebrand's disease) in a Chesapeake Bay Retriever.

Abstract

A bleeding disease similar to von Willebrand's disease in man was diagnosed in a 6-month-old Chesapeake Bay Retriever with recurrent, protracted gingival hemorrhage that responded rapidly to fresh, whole blood transfusions. The dog had a prolonged bleeding time and low plasma factor VIII coagulant activity (18%). The plasma had no detectable factor VIII-related antigen or von Willebrand factor, as measured by ristocetin-cofactor and polybrene-cofactor activities. The dam of the dog had a plasma factor VIII-related antigen concentration (32%) well below the normal range. The antigen in the sire's plasma was at the low end of the normal range, as was the polybrene-cofactor of both the sire and the dam. These data suggested an inherited basis for von Willebrand's disease in this dog.

• Authors: G S Johnson, G E Lees, R E Benson, T K Rosborough, W J Dodds
• Journal: Journal of the American Veterinary Medical Association (J Am Vet Med Assoc) Vol. 176 Issue 11 Pg. 1261-3 (Jun 01 1980) ISSN: 0003-1488 [Print] United States
• PMID: 6776082 (Publication Type: Case Reports, Comparative Study, Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• von Willebrand Factor
• Factor VIII

Topics

• Animals
• Dog Diseases (blood, genetics)
• Dogs
• Factor VIII (analysis)
• Male
• von Willebrand Diseases (blood, genetics, veterinary)
• von Willebrand Factor (analysis)