Abstract |
Serological and structural changes of surface markers involved in immune reactions may occur in human and murine tumour systems. Thus nine out of twenty-one human tumour cell lines and SV40-transformed fibroblasts differed from autologous lymphoblastoid cells or fibroblasts in their reactivity with HLA alloantisera. H-2 antigens isolated from the murine tumour cells 6C3HED and TP1422, undergo structural changes. An alien HLA-B7 was detected in sera from two melanoma patients. The serologic activity of H-2 antigens was significantly increased in the serum and ascites fluid of tumour bearing mice. Additionally, human SV40-transformed fibroblasts acquire receptors for monkey red blood cells and the murine lymphosarcoma cells 6C3HED express receptors for sheep red blood cells.
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Authors | S Ferrone, M A Pellegrino, G N Callahan |
Journal | Journal of immunogenetics
(J Immunogenet)
Vol. 7
Issue 1
Pg. 71-9
(Feb 1980)
ISSN: 0305-1811 [Print] England |
PMID | 6768809
(Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- H-2 Antigens
- Staphylococcal Protein A
- beta-Aminoethyl Isothiourea
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Topics |
- Animals
- Cell Line
- Cell Membrane
(immunology)
- Fibroblasts
(immunology)
- Genetic Code
- H-2 Antigens
- Haplorhini
- Humans
- Lymphoma
(immunology)
- Major Histocompatibility Complex
- Melanoma
(immunology)
- Mice
- Rosette Formation
- Staphylococcal Protein A
(immunology)
- beta-Aminoethyl Isothiourea
(pharmacology)
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