Experimental osteomyelitis caused by Pseudomonas aeruginosa.

Abstract

An experimental model of chronic osteomyelitis caused by Pseudomonas aeruginosa was established with use of techniques identical to those employed previously with Staphylococcus. Infection of bone was consistently produced, but the disease was less severe than that seen with Staphylococcus. There were lower mortality, decreased severity of infection as demonstrated by X ray, and less evidence of sequestrum formation with P. aeruginosa than with Staphylococcus. Carbenicillin was used alone and in combination with sisomicin in the treatment of experimental pseudomonas osteomyelitis. The combination, when administered for four weeks, was significantly more effective than either agent alone.

• Authors: C W Norden, E Keleti
• Journal: The Journal of infectious diseases (J Infect Dis) Vol. 141 Issue 1 Pg. 71-5 (Jan 1980) ISSN: 0022-1899 [Print] United States
• PMID: 6767790 (Publication Type: Journal Article)

Chemical References

• Gentamicins
• Sodium Morrhuate
• Carbenicillin
• Sisomicin

Topics

• Animals
• Carbenicillin (therapeutic use)
• Disease Models, Animal
• Drug Evaluation, Preclinical
• Drug Therapy, Combination
• Gentamicins (therapeutic use)
• Humans
• Kidney (physiology)
• Male
• Microbial Sensitivity Tests
• Osteomyelitis (diagnostic imaging, drug therapy, etiology, microbiology, pathology)
• Pseudomonas Infections
• Pseudomonas aeruginosa (drug effects, pathogenicity)
• Radiography
• Sisomicin (therapeutic use)
• Sodium Morrhuate (pharmacology)