HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Immunoglobulin production in lymphomatoid granulomatosis and relation to other "benign" lymphoproliferative disorders.

Abstract
Immunoperoxidase technics were used to examine the immunoglobulin content of sections of pulmonary tissue from two typical cases of lymphomatoid granulomatosis and two cases of pneumonic processes initially diagnosed as lymphomatoid granulomatosis but representing different processes on review. Both "typical" cases and one of the others had a predominantly mixed pattern of all immunoglobulins. One "typical" case showed a focus of exclusively IgG/K staining, which corresponded to histologic malignancy. Less than 1% of cells stained in the fourth case. These results demonstrate that several different processes may fit the morphologic criteria of lymphomatoid granulomatosis; that there is a group of cases that typify lymphomatoid granulomatosis clinically and histologically, and that these cases represent a B-cell proliferation that is initially polyclonal but may evolve into immunoblastic sarcoma. "Typical" cases are similar to other lymphoreticular proliferations with malignant potential, such as angioimmunoblastic lymphadenopathy and Sjögren's syndrome.
AuthorsB L Bender, R Jaffe
JournalAmerican journal of clinical pathology (Am J Clin Pathol) Vol. 73 Issue 1 Pg. 41-7 (Jan 1980) ISSN: 0002-9173 [Print] England
PMID6766270 (Publication Type: Case Reports, Comparative Study, Journal Article)
Chemical References
  • Immunoglobulin G
  • Immunoglobulin kappa-Chains
  • Immunoglobulin lambda-Chains
  • Immunoglobulins
Topics
  • B-Lymphocytes (immunology)
  • Female
  • Humans
  • Immunoglobulin G
  • Immunoglobulin kappa-Chains
  • Immunoglobulin lambda-Chains
  • Immunoglobulins (biosynthesis)
  • Lymphomatoid Granulomatosis (immunology, pathology)
  • Lymphoproliferative Disorders (immunology, pathology)
  • Male
  • Middle Aged

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: