Growth hormone secretion in empty sella syndrome.

Abstract

GH secretion was studied in 47 patients with empty sella syndrome (ESS), using the GH response to the L-dopa test and determinations of the somatomedin levels. A high frequency of low responders (56%) was found, which is in accordance with previous reports on ESS. However, a true GH deficiency as judged by low levels of somatomedin A, was suspected in only 2 out of 41 patients with otherwise normal pituitary function and in 5 out of 6 patients with other pituitary insufficiences. The impaired GH responsiveness in the remaining patients seemed to be attributed to their overweight and/or postmenopausal age (estrogen deficiency) and not to a true GH deficiency, which was excluded by normal levels of somatomedin.

• Authors: K Brismar
• Journal: Journal of endocrinological investigation (J Endocrinol Invest) 1982 Nov-Dec Vol. 5 Issue 6 Pg. 417-22 ISSN: 0391-4097 [Print] Italy
• PMID: 6763056 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Insulin
• Somatomedins
• Levodopa
• Insulin-Like Growth Factor II
• Growth Hormone

Topics

• Adolescent
• Adult
• Aged
• Empty Sella Syndrome (physiopathology)
• Female
• Growth Hormone (deficiency, metabolism)
• Humans
• Hypoglycemia (chemically induced, physiopathology)
• Insulin (pharmacology)
• Insulin-Like Growth Factor II
• Levodopa (pharmacology)
• Male
• Middle Aged
• Somatomedins (blood)