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Stimulation of resistance of immunocompromised mice by a muramyl dipeptide analog.

Abstract
L18-MDP(Ala), a synthetic derivative of muramyl dipeptide, enhanced resistance against Escherichia coli and Candida albicans infections in aged mice and younger adult mice whose defense mechanism(s) had been depressed by X-ray irradiation or by treatment with cyclophosphamide.
AuthorsY Osada, M Mitsuyama, K Matsumoto, T Une, T Otani, H Ogawa, K Nomoto
JournalInfection and immunity (Infect Immun) Vol. 37 Issue 3 Pg. 1285-8 (Sep 1982) ISSN: 0019-9567 [Print] United States
PMID6752024 (Publication Type: Journal Article)
Chemical References
  • Adjuvants, Immunologic
  • Acetylmuramyl-Alanyl-Isoglutamine
  • 6-O-stearoyl-N-acetylmuramyl-alanylisoglutamine
Topics
  • Acetylmuramyl-Alanyl-Isoglutamine (analogs & derivatives, pharmacology)
  • Adjuvants, Immunologic (pharmacology)
  • Aging
  • Animals
  • Candidiasis (immunology)
  • Escherichia coli Infections (immunology)
  • Immunity, Innate
  • Immunosuppression Therapy
  • Male
  • Mice

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