Adrenal adenoma with 18-hydroxycorticosterone excess and hypertension: a variant of aldosteronomas.

Abstract

A 46-year-old woman with hypertension, normokalemia, suppressed renin, normal catecholamines, and a left adrenal mass on the CT scan was found to have excessive 18-hydroxycorticosterone (18-OHB) and normal aldosterone levels in plasma, both of which responded poorly to sodium restriction and angiotension II, and supranormally to ACTH. Plasma 18-hydroxydeoxycorticosterone (18-OHDOC) was normal. After adrenalectomy, amelioration from hypertension occurred with a reduction in plasma 18-OHB and aldosterone. The plasma 18-OHDOC remained normal. The adrenal tumor was histologically an adenoma, containing a large amount of 18-OHB and a small amount of aldosterone. Thus, the present adenoma seems to be a variant of aldosteronomas.

• Authors: T Kigoshi, N Imaizumi, S Azukizawa, I Yamamoto, H Hosojima, K Uchida, S Morimoto
• Journal: Hormone research (Horm Res) Vol. 19 Issue 4 Pg. 224-31 ( 1984) ISSN: 0301-0163 [Print] Switzerland
• PMID: 6745843 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Aldosterone
• 18-Hydroxycorticosterone
• Corticosterone

Topics

• 18-Hydroxycorticosterone (blood)
• Adenoma (blood, complications, pathology)
• Adrenal Gland Neoplasms (blood, complications, pathology)
• Aldosterone (blood)
• Corticosterone (analogs & derivatives)
• Female
• Humans
• Hypertension (blood, etiology, pathology)
• Middle Aged