Blocking effect of verapamil on conduction over a catecholamine-sensitive bypass tract in exercise-induced Wolff-Parkinson-White syndrome.

Abstract

By intravenous administration of isoproterenol, 0.5 micrograms/min, a catecholamine-sensitive bypass tract was confirmed in two patients with exercise-induced Wolff-Parkinson-White syndrome. In a 24 year old woman, an intravenous bolus injection of 5 mg of verapamil suddenly blocked conduction over a catecholamine-sensitive bypass tract. In a 62 year old man, the exercise-induced Wolff-Parkinson-White syndrome disappeared after 3 days of oral administration of verapamil (120 mg/day). These observations suggest that a slow inward calcium current plays an important role in conduction over a catecholamine-sensitive bypass tract in exercise-induced Wolff-Parkinson-White syndrome.

• Authors: Y Horio, K Matsuyama, Y Morikami, M Rokutanda, A Hirata, K Okumura, K Takaoka, H Uchida, K Kugiyama, S Araki
• Journal: Journal of the American College of Cardiology (J Am Coll Cardiol) Vol. 4 Issue 1 Pg. 186-91 (Jul 1984) ISSN: 0735-1097 [Print] United States
• PMID: 6736448 (Publication Type: Case Reports, Journal Article)

Chemical References

• Catecholamines
• Verapamil
• Isoproterenol

Topics

• Adult
• Cardiac Pacing, Artificial
• Catecholamines (physiology)
• Electrocardiography
• Exercise Test
• Female
• Heart Conduction System (drug effects, physiopathology)
• Humans
• Isoproterenol (pharmacology)
• Male
• Middle Aged
• Verapamil (pharmacology, therapeutic use)
• Wolff-Parkinson-White Syndrome (drug therapy, physiopathology)