Comparison of dicyclomine with antacid and without antacid in dyspepsia.

In a study of forty-two patients with dyspepsia, hiatus hernia or duodenal ulcer, dicyclomine (Merbentyl) has been demonstrated to be effective in the control of the symptoms of this disorder. Under double-blind conditions an antacid or placebo supplement was provided and no significant difference in benefit was recorded. The antacid was given in a large tablet and this preparation was more conscientiously taken by patients, and this was equally true for large placebo tablets. Clearly patients like to take frequent treatment for dyspepsia, but symptom control is quite adequate if Merbentyl is given alone.
AuthorsG Kagan, L Huddlestone, P Wolstencroft
JournalThe Journal of international medical research (J Int Med Res) Vol. 12 Issue 3 Pg. 174-8 ( 1984) ISSN: 0300-0605 [Print] England
PMID6734920 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
Chemical References
  • Antacids
  • Cyclohexanecarboxylic Acids
  • Dicyclomine
  • Antacids (adverse effects, therapeutic use)
  • Cyclohexanecarboxylic Acids (therapeutic use)
  • Dicyclomine (adverse effects, therapeutic use)
  • Double-Blind Method
  • Drug Evaluation
  • Drug Therapy, Combination
  • Dyspepsia (drug therapy)
  • Humans

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