Chromosome studies in polycythemia vera patients.

Abstract

One hundred thirty-five polycythemia vera (PV) patients (30 untreated by chemotherapy and 105 treated) were studied cytogenetically . The incidence of clonal chromosomal abnormalities was 20.7% (28 patients in nonleukemic phase). The incidence of 20q - was 3.7% (5 patients). The presence of cytogenetically abnormal clones did not allow prediction of the evolution of the disease. In a few cases, abnormal clones disappeared at the time of later studies. Although nonrandom, the majority of clonal chromosomal abnormalities are believed to be secondary events in PV patients.

• Authors: R Berger, A Bernheim, M Le Coniat, D Vecchione, G Flandrin, C Dresch, Y Najean
• Journal: Cancer genetics and cytogenetics (Cancer Genet Cytogenet) Vol. 12 Issue 3 Pg. 217-23 (Jul 1984) ISSN: 0165-4608 [Print] United States
• PMID: 6722763 (Publication Type: Journal Article)

Topics

• Aged
• Chromosome Aberrations (genetics)
• Chromosome Disorders
• Female
• Humans
• Karyotyping
• Male
• Middle Aged
• Polycythemia Vera (genetics)