[Breast cancer--topics from basic research].

Abstract

The measurement of estrogen and progesterone receptors in human breast cancer provides useful markers for predicting response to endocrine therapy. In human breast cancer, about 90% of unresponsive tumors and 60-80% of tumors responsive to endocrine therapy can be predicted by receptor measurement. Hormone-dependency of breast cancer easily disappears, and endocrine therapy for hormone-dependent cancer markedly encourages disappearance. Since very useful non-steroidal antiestrogens have been synthesized recently, the usefulness of drug-based endocrine therapy for breast cancer has become more important compared with brought about by surgical therapy. To improve the effectiveness of endocrine therapy for hormone-dependent cancer, the proliferation of hormone-independent cancer cells developing from hormone-dependent cancer cells during endocrine therapy should be inhibited. For inhibition, chemotherapy combined with the endocrine therapy and adjuvant endocrine therapy seem to be useful methods for the future.

• Authors: K Matsumoto, H Kuroda, M Takeyama
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 11 Issue 5 Pg. 974-80 (May 1984) ISSN: 0385-0684 [Print] Japan
• PMID: 6721515 (Publication Type: English Abstract, Journal Article)

Chemical References

• Receptors, Estrogen
• Receptors, Progesterone
• Tamoxifen
• Melphalan
• Fluorouracil

Topics

• Animals
• Breast Neoplasms (analysis, drug therapy)
• Female
• Fluorouracil (administration & dosage)
• Humans
• Melphalan (administration & dosage)
• Mice
• Neoplasms, Hormone-Dependent (analysis, drug therapy)
• Rats
• Receptors, Estrogen (analysis)
• Receptors, Progesterone (analysis)
• Tamoxifen (administration & dosage)