HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Hyperactivity induced by prenatal administration of methylazoxymethanol: association with altered performance on conditioning tasks in rats.

Abstract
Methylazoxymethanol (MAM), an alkylating agent which kills dividing cells, produces microcephaly when administered to rats at 15 days gestation. Rats treated prenatally with MAM were tested on a variety of behavioral tests. The MAM-treated animals performed better than controls in the acquisition of a food-reinforced operant response, but poorer than controls on a passive avoidance procedure. When required to reverse the passive avoidance procedure by actively avoiding the portion of a chamber that was associated with shock, MAM-treated rats performed better than controls. The MAM-treated rats were microcephalic and were also hyperactive compared to controls. It was postulated that the behavioral changes observed in the conditioning tasks may be attributable to hyperactivity. A possible neurochemical basis for this hyperactivity is discussed.
AuthorsH E Cannon-Spoor, W J Freed
JournalPharmacology, biochemistry, and behavior (Pharmacol Biochem Behav) Vol. 20 Issue 2 Pg. 189-93 (Feb 1984) ISSN: 0091-3057 [Print] United States
PMID6718446 (Publication Type: Journal Article)
Chemical References
  • Alkylating Agents
  • Azo Compounds
  • Methylazoxymethanol Acetate
  • methylazoxymethanol
Topics
  • Alkylating Agents (pharmacology)
  • Animals
  • Avoidance Learning (drug effects)
  • Azo Compounds (pharmacology)
  • Body Weight
  • Conditioning, Operant (drug effects)
  • Female
  • Methylazoxymethanol Acetate (analogs & derivatives, pharmacology)
  • Motor Activity (drug effects)
  • Pregnancy
  • Prenatal Exposure Delayed Effects
  • Psychomotor Performance (drug effects)
  • Rats
  • Rats, Inbred Strains

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: