[Effect of current anti-inflammatory agents on the reparative stage of inflammation].

Abstract

The action on the reparative stage of inflammation of acetylsalicylic, ascorbic and mephenamic acids, amidopyrine, analgin, butadion, ibuprophen, indomethacin, voltaren, glycyrrhizic acid and its penta-O-nicotinate, delagil, methyluracil, and prednisolone was evaluated from the rate of the healing of skin wounds in mice and rats, formation of the granulation tissue on the integmentary glass implanted into the subcutaneous fat from the effect on the functional status of fibroblast chromatin and changes in phagocytosis. Prednisolone, indomethacin voltaren, delagil, appeared to inhibit whereas amidopyrine, acetylsalicylic acid, butadion, ibuprophen and methyluracil to stimulate the reparative stage of inflammation. The anti-inflammatory agents that stimulated reparative regeneration raised the functional activity of chromatin.

• Authors: Kh M Nasyrov, D N Lazareva
• Journal: Farmakologiia i toksikologiia (Farmakol Toksikol) 1984 Jan-Feb Vol. 47 Issue 1 Pg. 84-8 ISSN: 0014-8318 [Print] Russia (Federation)
• Vernacular Title: Vliianie sovremennykh protivovospalitel'nykh sredstv na reparativnuiu stadiiu vospaleniia.
• PMID: 6705906 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Anti-Inflammatory Agents
• Chromatin

Topics

• Animals
• Anti-Inflammatory Agents (therapeutic use)
• Chromatin (drug effects)
• Granulation Tissue (drug effects)
• Inflammation (drug therapy)
• Mice
• Microscopy, Fluorescence
• Phagocytosis (drug effects)
• Rats
• Skin (injuries)
• Time Factors
• Wound Healing (drug effects)