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Double-blind placebo-controlled trial of flunarizine as add-on therapy in epilepsy.

Abstract
In a therapy-resistant epileptic population with partial complex seizures with or without secondary generalization, addition of flunarizine to existing therapy was accompanied by a significant reduction in complex partial and tonic-clonic seizures. This result did not appear to be due to serial effects or changes in the plasma levels of the co-medication. Side effects were rare. The serum flunarizine levels (13.8 ng/ml; range, 3-32.5 ng/ml) were lower than previously reported on a daily dose of 10 mg. This may reflect increased metabolism due to induction of liver enzymes by the co-medication. Given this finding, together with the low incidence of side effects, a further study is required to determine whether higher blood levels would give an improved degree and incidence of seizure reduction.
AuthorsJ Overweg, C D Binnie, J W Meijer, H Meinardi, S T Nuijten, S Schmaltz, A Wauquier
JournalEpilepsia (Epilepsia) Vol. 25 Issue 2 Pg. 217-22 (Apr 1984) ISSN: 0013-9580 [Print] United States
PMID6705752 (Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article)
Chemical References
  • Piperazines
  • Vasodilator Agents
  • Cinnarizine
  • Flunarizine
Topics
  • Adolescent
  • Adult
  • Cinnarizine (adverse effects, analogs & derivatives, therapeutic use)
  • Drug Therapy, Combination
  • Epilepsy (drug therapy)
  • Female
  • Flunarizine
  • Humans
  • Male
  • Middle Aged
  • Piperazines (therapeutic use)
  • Vasodilator Agents (therapeutic use)

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