Effect of thyroxine-induced hyperthyroidism on some testicular enzymes of the pyruvate/malate cycle.

Abstract

The effect of thyroxine on the specific activities of testicular enzymes of the pyruvate/malate cycle involved in lipogenesis were studied in prepubertal, pubertal and adult rats. Thyroxine (25 micrograms/100 g body weight) treatment for 1 month increased the specific activity of isocitrate dehydrogenase (NADP+) but the specific activities of ATP-citrate lyase, malate dehydrogenase and malic enzyme were inhibited. Withdrawal of thyroxine treatment from hyperthyroid rats brought back all enzyme activities to normal. The study reveals a direct, specific influence of thyroxine on different testicular enzymes of the pyruvate/malate cycle.

• Authors: M M Aruldhas, H M Valivullah, P Govindarajulu
• Journal: Biochimica et biophysica acta (Biochim Biophys Acta) Vol. 797 Issue 2 Pg. 143-6 (Feb 14 1984) ISSN: 0006-3002 [Print] Netherlands
• PMID: 6696944 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Malates
• Pyruvates
• Pyruvic Acid
• Malate Dehydrogenase
• Isocitrate Dehydrogenase
• D-malate dehydrogenase (decarboxylating)
• ATP Citrate (pro-S)-Lyase
• Thyroxine

Topics

• ATP Citrate (pro-S)-Lyase (metabolism)
• Animals
• Hyperthyroidism (chemically induced, enzymology)
• Isocitrate Dehydrogenase (metabolism)
• Malate Dehydrogenase (metabolism)
• Malates (metabolism)
• Male
• Pyruvates (metabolism)
• Pyruvic Acid
• Rats
• Rats, Inbred Strains
• Sexual Maturation
• Testis (enzymology, growth & development)
• Thyroxine (toxicity)