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Experimental Staphylococcus epidermidis endocarditis in rabbit model.

Abstract
To study the natural course of catheter-induced endocarditis secondarily infected with Staphylococcus epidermidis, 29 rabbits had catheters introduced surgically through the carotid artery to the aortic valve. Forty-eight hours later the catheters were removed from five rabbits. The rabbits were inoculated intravenously with 10(8) colony-forming units of S epidermidis. Autopsies done at various intervals showed all rabbits with indwelling catheters had noticeable aortic valve vegetations with positive cultures for S epidermidis. In the group with catheters removed after 48 hours, less severe valvular lesions were noted. Metastatic seeding to kidneys, spleen, and liver were noted in both groups. Because of low cure rate in the treatment of S epidermidis endocarditis, this rabbit model could be used to study antibiotic regimens for valvular endocarditis.
AuthorsD Shamsuddin, C U Tuazon, H Miller, A K Shamsuddin, D Friedman
JournalArchives of pathology & laboratory medicine (Arch Pathol Lab Med) Vol. 107 Issue 3 Pg. 141-3 (Mar 1983) ISSN: 0003-9985 [Print] United States
PMID6687530 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Topics
  • Animals
  • Aortic Valve (pathology)
  • Disease Models, Animal
  • Endocarditis, Bacterial (etiology, pathology)
  • Endocardium (microbiology)
  • Female
  • Heart Valve Prosthesis (adverse effects)
  • Kidney (microbiology)
  • Liver (microbiology)
  • Rabbits
  • Spleen (microbiology)
  • Staphylococcal Infections (etiology, pathology)

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