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Efficacy of triclabendazole against Fasciola hepatica in sheep and goats.

Abstract
Triclabendazole (Fasinex), a new fasciolicide of the benzimidazole group, was tested in sheep and goats. A controlled test with 24 artificially-infected sheep revealed a 100% efficacy of triclabendazole at a dose of 10 mg kg-1 body weight against Fasciola hepatica aged 4 and 13 weeks, respectively. In naturally-acquired severe subacute to chronic fascioliasis in 66 sheep and 10 goats, the drug was highly effective in three trials when applied at 10 mg kg-1 in sheep and at 5 mg kg-1 in goats. Triclabendazole was well tolerated, whereas side effects occurred in one trial with niclofolan (Bilevon-M) (3 mg kg-1) which was used for comparison.
AuthorsK Wolff, J Eckert, G Schneiter, H Lutz
JournalVeterinary parasitology (Vet Parasitol) Vol. 13 Issue 2 Pg. 145-50 (Sep 1983) ISSN: 0304-4017 [Print] Netherlands
PMID6685399 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • Anthelmintics
  • Benzimidazoles
  • Triclabendazole
  • Niclofolan
Topics
  • Animals
  • Anthelmintics (pharmacology, therapeutic use)
  • Benzimidazoles (pharmacology)
  • Fasciola hepatica (drug effects)
  • Fascioliasis (drug therapy, parasitology, veterinary)
  • Feces (parasitology)
  • Goats (parasitology)
  • Niclofolan (pharmacology, therapeutic use)
  • Parasite Egg Count (veterinary)
  • Sheep
  • Sheep Diseases (drug therapy, parasitology)
  • Triclabendazole

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