Abstract |
Triclabendazole ( Fasinex), a new fasciolicide of the benzimidazole group, was tested in sheep and goats. A controlled test with 24 artificially-infected sheep revealed a 100% efficacy of triclabendazole at a dose of 10 mg kg-1 body weight against Fasciola hepatica aged 4 and 13 weeks, respectively. In naturally-acquired severe subacute to chronic fascioliasis in 66 sheep and 10 goats, the drug was highly effective in three trials when applied at 10 mg kg-1 in sheep and at 5 mg kg-1 in goats. Triclabendazole was well tolerated, whereas side effects occurred in one trial with niclofolan ( Bilevon-M) (3 mg kg-1) which was used for comparison.
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Authors | K Wolff, J Eckert, G Schneiter, H Lutz |
Journal | Veterinary parasitology
(Vet Parasitol)
Vol. 13
Issue 2
Pg. 145-50
(Sep 1983)
ISSN: 0304-4017 [Print] Netherlands |
PMID | 6685399
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Anthelmintics
- Benzimidazoles
- Triclabendazole
- Niclofolan
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Topics |
- Animals
- Anthelmintics
(pharmacology, therapeutic use)
- Benzimidazoles
(pharmacology)
- Fasciola hepatica
(drug effects)
- Fascioliasis
(drug therapy, parasitology, veterinary)
- Feces
(parasitology)
- Goats
(parasitology)
- Niclofolan
(pharmacology, therapeutic use)
- Parasite Egg Count
(veterinary)
- Sheep
- Sheep Diseases
(drug therapy, parasitology)
- Triclabendazole
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