[Fundamental and clinical studies on T-1982 (cefbuperazone) in the field of obstetrics and gynecology].

Abstract

Fundamental and clinical studies were made on T-1982 (cefbuperazone) and the results were obtained as follows. Serum and uterine tissue concentrations of T-1982 were determined at 26 minutes before and at 20 to 80 minutes after the completion of intravenous drip infusion of 1 g. The levels of T-1982 in the fallopian tube, ovarium, endometrium, myometrium and uterine cervix were 23.7, 19.5, 50.5, 10.9 micrograms/g and 17.5 micrograms/g at 20 minutes after the completion of infusion. The levels were sufficiently effective against major pathogens (Gram negative bacteria and anaerobic bacilli) isolated in the field of obstetrics and gynecology. T-1982 was administered to 11 patients, including 7 of acute adnexitis, each one of pelveoperitonitis, pyometra, puerperal fever, and 1 of puerperal fever with sepsis, at a dose of 1-2 g twice a day for a period of 5 to 9 days by intravenous injection or intravenous drip infusion. Clinical responses were excellent in 5, good in 3 and poor in 3. No adverse reactions nor marked changes in laboratory findings were observed in any of the cases treated with T-1982.

• Authors: H Nakamura, Y Iwata, S Hayashi
• Journal: The Japanese journal of antibiotics (Jpn J Antibiot) Vol. 36 Issue 5 Pg. 956-62 (May 1983) ISSN: 0368-2781 [Print] Japan
• PMID: 6684699 (Publication Type: Journal Article)

Chemical References

• Cephamycins
• cefbuperazone

Topics

• Adolescent
• Adult
• Aged
• Cephamycins (analysis, therapeutic use)
• Female
• Humans
• Middle Aged
• Ovary (analysis, blood supply)
• Pelvic Inflammatory Disease (drug therapy)
• Pregnancy
• Puerperal Infection (drug therapy)
• Uterus (analysis)