[Effect of co-dergocrine mesylate on catecholamines and prolactin in elderly hypertensive patients].

Abstract

The antihypertensive efficacy of co-dergocrine mesylate (a mixture of dihydroergocornine mesylate, dihydroergocristine mesylate, and alpha- and beta-dihydroergocryptine mesylates; Hydergin) and its effects on heart rate, plasma catecholamines, catecholamine excretion and plasma prolactin was tested in 12 elderly hypertensive patients. Co-dergocrine mesylate (6 mg or 12 mg, 1 or 2 tablets once a day) caused a significant reduction of the blood pressure during rest and under physical stress without a reactive increase of the heart rate. Plasma norepinephrine and prolactin as well as urinary excretion of norepinephrine and epinephrine were not affected by co-dergocrine mesylate. The therapeutic advantage of co-dergocrine mesylate for the treatment of hypertension in the elderly is discussed.

• Authors: R Mies, R Lang, G Weidinger, D Welzel
• Journal: Arzneimittel-Forschung (Arzneimittelforschung) Vol. 33 Issue 5 Pg. 771-3 ( 1983) ISSN: 0004-4172 [Print] Germany
• Vernacular Title: Wirkung von Co-Dergocrinmesylat auf Katecholamine und Prolaktin bei älteren Hypertonikern.
• PMID: 6683557 (Publication Type: English Abstract, Journal Article)

Chemical References

• Antihypertensive Agents
• Catecholamines
• Dihydroergotoxine
• Prolactin

Topics

• Aged
• Antihypertensive Agents
• Catecholamines (blood)
• Dihydroergotoxine (pharmacology)
• Female
• Humans
• Hypertension (blood, physiopathology)
• Male
• Middle Aged
• Prolactin (blood)