Encephalopathy in rats and nephropathy in rats and mice after subchronic oral exposure to benzaldehyde.

Abstract

Male and female Fischer 344 rats and B6C3F1 mice were treated daily (5 days/wk) with benzaldehyde by gavage either in 12 doses of 0 (vehicle control), 100 (rats only), 200, 400, 800, 1600 or (for mice only) 3200 mg/kg body weight/day (followed by 2 days' observation without treatment), or for 90 days in doses of 0, 50, 100, 200, 400 or 800 mg/kg/day (rats) or 0, 75, 150, 300, 600 or 1200 mg/kg/day (mice). In the acute studies, benzaldehyde induced deaths and decreased body-weight gain in both sexes of rats given 800 or 1600 mg/kg/day and caused deaths in both sexes of mice given 1600 or 3200 mg/kg/day. In the 90-day studies, deaths occurred in both sexes of rats on 800 mg/kg/day and in male mice on 1200 mg/kg/day. Body-weight gain was depressed in male rats on 800 mg/kg/day, in male mice on 600 mg/kg/day and in female mice on 1200 mg/kg/day. Necrotic and degenerative lesions were seen in the cerebellar and hippocampal regions of the brain in both sexes of rats given 800 mg/kg/day, but not in mice. Renal tubular necrosis occurred in male and female rats on 800 mg/kg/day and in male mice on 1200 mg/kg/day. Mild epithelial hyperplasia or hyperkeratosis of the forestomach was seen in male and female rats on 800 mg/kg/day. In this limited study, the no-observed-toxic-effect doses of benzaldehyde administered by gavage were 400 mg/kg/day in male and female rats, 300 mg/kg/day in male mice and 600-1200 mg/kg/day in female mice.

• Authors: W M Kluwe, C A Montgomery, H D Giles, J D Prejean
• Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association (Food Chem Toxicol) Vol. 21 Issue 3 Pg. 245-50 (Jun 1983) ISSN: 0278-6915 [Print] England
• PMID: 6683220 (Publication Type: Journal Article)

Chemical References

• Benzaldehydes

Topics

• Administration, Oral
• Animals
• Benzaldehydes (toxicity)
• Brain (pathology)
• Brain Diseases (chemically induced)
• Dose-Response Relationship, Drug
• Female
• Kidney (pathology)
• Kidney Diseases (chemically induced)
• Male
• Mice
• Mice, Inbred Strains
• Rats
• Rats, Inbred F344